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Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Medicinal Chemistry Summary: The project will involve multi-step organic synthesis. While working on the target molecules, the student intern will gain hands-on experience in multi-step synthetic techniques and modern spectroscopic methods. Additionally, the intern will be immersed in the scientific environment at Ionis, reinforcing their interest in science—one of the key goals of our internship program. Qualifications: Currently enrolled as a Chemistry major with experience in organic chemistry laboratory work Knowledge of organic chemistry lab safety practices preferred Program Highlights: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Requirements: MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be able and willing to commit to a minimum 40-hour work week. Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Lead Identification – NGS group SUMMARY: We are seeking an enthusiastic and highly motivated undergraduate student who is currently enrolled in a molecular or cellular biology-based program to join the Lead Identification – NGS group as a 2026 summer intern. The intern will work within a fast-paced, highly productive, and collaborative research environment and have the opportunity to make impactful contributions to Ionis’ RNA sequencing (RNAseq) workflow in support of drug discovery. This internship project will focus on implementing and optimizing a new RNAseq assay. The intern will gain hands-on experience with library preparation, lab liquid handlers, and next-generation sequencing. The goal of the project is to compare our current workflow to a new, multiplexed workflow to increase throughput of RNAseq samples while maintaining high data quality. RESPONSIBILITIES: Learn and perform the current RNAseq library preparation protocol to establish a quality benchmark Assist in optimizing the multiplexed RNAseq protocol to increase assay throughput Support and learn to write protocols on liquid handlers Assist with optimization of automation conditions Learn to QC RNAseq libraries Load sequencers and understand basic QC metrics Collaborate with scientists across NGS and automation teams to refine workflows Present project results at the end of the internship program. REQUIREMENTS: Must be enrolled in an undergraduate molecular biology, cell biology or other related program Must have completed one quarter/semester of biology or chemistry lab-based coursework Must be able to commit to full 10 week program Must be able to commit to 40 hour work week and work onsite in Carlsbad, CA MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. PROGRAM HIGHLIGHTS: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Pulmonary Drug Discovery Role overview: Support a preclinical project to compare two RNA-therapeutic strategies for non-cystic fibrosis bronchiectasis using an established mouse model and standard molecular/phenotypic endpoints to help determine the optimal therapeutic approach. Responsibilities (under supervision/training): Execute and help optimize an NCFB-like mouse model protocol (building on published/internal methods) and ensure proper controls and documentation Support in vivo study activities (rodent handling, dosing, tissue collection) following SOPs and animal welfare requirements Process samples (tissue homogenization, RNA extraction) and quantify key markers of inflammation and muco-obstruction using qPCR, ELISA or related assays Organize/analyze data and communicate results via weekly updates and a final summary/presentation Success criteria by end of internship: a reproducible model protocol + a comparative dataset and recommendation on strategy. Program Highlights: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Requirements: MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be able and willing to commit to a minimum 40-hour work week. Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Corporate Operations (Launch Readiness) Summary The Corporate Operations team takes on complex enterprise initiatives to drive organizational performance and outcomes. As a member of this team, you will support Ionis’s cross-functional launch readiness efforts for upcoming product launches, including TRYNGOLZA for sHTG and zilganersen for Alexander’s Disease. The Corporate Operations Summer Intern will contribute to key launch readiness activities spanning pre-launch planning to post-launch support. Working across enabling functions such as Accounting, Finance, HR, IT, Quality, Safety/PV, and Legal, they will help coordinate key activities, track milestones, and identify potential risks to ensure alignment across teams. This experience will provide the intern with exposure to how diverse teams prepare for commercialization and what it takes to bring a product to market. The intern will build skills in leadership, strategic project management, and cross-functional collaboration while contributing to Ionis’s overall launch readiness success. Responsibilities Own the preparation and follow-through for cross-functional launch readiness meetings, including shaping agendas, synthesizing discussions, and tracking decisions and commitments Manage launch readiness trackers and status dashboards, ensuring accuracy and providing visibility into progress across enabling functions in support of Commercial readiness Identify risks, gaps, and dependencies and proactively communicate findings to support informed decision-making and mitigation strategies Prepare executive-level presentations for Commercial and leadership that consolidate updates from enabling teams (e.g., Finance, HR, IT, Quality, Safety/PV, Legal) Contribute to ad hoc project work that supports alignment between enabling functions and Commercial teams throughout pre-launch and post-launch activities Requirements Currently pursuing a bachelor’s or master’s degree in business, life sciences, public health, engineering or a related field Strong organizational and time management skills, with the ability to support multiple workstreams simultaneously Clear and effective written and verbal communication skills Ability to work collaboratively with diverse teams and stakeholders Comfortable working in a dynamic environment with shifting priorities and timelines Interested in learning about pharmaceutical commercialization, launch readiness, and cross-functional operations in a collaborative environment Program Highlights: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Requirements: MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be able and willing to commit to a minimum 40-hour work week. Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Antibody Engineering Role Overview The summer intern will work on a cutting-edge ligand engineering project focused on optimizing Blood-Brain Barrier (BBB) ligands for the delivery of oligonucleotides. This involves applying protein engineering techniques and leveraging yeast surface display technology to identify novel clones with improved central nervous system (CNS) delivery of oligonucleotide payloads. Key Responsibilities Protein Engineering: Perform high-throughput mutational scanning on BBB ligands to improve the delivery of oligonucleotides to the CNS. Yeast Culture Operation, Molecular Biology, and Surface Display: Implement and utilize yeast display platforms to present engineered variants for screening. Conjugation Analysis: Conjugate variants to oligonucleotides and assess conjugation efficiency. Functional Evaluation: Use multi-parameter flow cytometry to evaluate expression levels, antigen-binding functionality, and conjugation success. Data Interpretation: Analyze experimental results to identify mutants with improved CNS delivery. Learning & Development Opportunities Hands-on experience in molecular biology, protein biochemistry, and flow cytometry. Exposure to advanced antibody engineering strategies and ligand design. Opportunity to contribute to a project with potential for publication and real-world impact. Expectations Strong interest in biotechnology, molecular biology, or related fields. Ability to work independently and collaboratively in a research environment. Attention to detail and willingness to learn new techniques. Commitment to scientific rigor and problem-solving. Program Highlights: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Requirements: MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be able and willing to commit to a minimum 40-hour work week. Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Pharmaceutical Development Summary: Ionis is offering a Summer Internship within our Pharmaceutical Development team for a motivated student interested in drug formulation, chemistry, and data driven research. This role provides hands on experience supporting the development of oligonucleotide-based medicines, including antisense oligonucleotides and siRNA therapeutics. The intern will work closely with an experienced scientist mentor on a research project focused on understanding how formulation components such as drug chemistry, pH, and buffering systems affect drug product performance. This internship is designed to help students connect classroom learning to real world pharmaceutical development while building strong technical and professional skills. What You Will Do Conduct laboratory experiments to evaluate formulation properties such as pH and buffer capacity Assist with experimental planning, sample preparation, and data collection Analyze and interpret experimental data using basic modeling and data analysis tools Learn how formulation decisions impact drug stability, quality, and patient experience Prepare summaries and presentations to share findings with the project team Collaborate with scientists across Pharmaceutical Development and related functions What You Will Learn Fundamentals of pharmaceutical formulation and drug product development How chemistry and molecular properties influence drug stability and performance Practical experience with experimental design, data analysis, and scientific communication Exposure to the research and development environment within a biotech company Professional skills through mentorship, teamwork, and presentations Who Should Apply Required Qualifications: Currently enrolled in a bachelors, masters, or doctoral program in Chemistry, Pharmaceutical Sciences, Chemical Engineering, Biochemistry, or a related field Completion of general and organic chemistry coursework or equivalent Strong interest in pharmaceutical or biotech research Ability to work independently and collaboratively in a laboratory setting Preferred Qualifications: Coursework or experience in organic chemistry, analytical chemistry, or pharmaceutics Familiarity with pH, buffers, or acid base chemistry Experience with data analysis tools such as Excel, JMP, Graphpad Prism Curiosity, attention to detail, and enthusiasm for learning Program Highlights: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite students only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Requirements: MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be able and willing to commit to a minimum 40-hour work week. Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Technology & AI Enablement Summary: We are seeking a motivated and technical Technology Intern to support initiatives across AI, Automation, and the Microsoft 365 ecosystem. This role is designed for a technical "builder" who wants to gain hands-on experience with modern enterprise tools like Databricks, SQL, and the Power Platform. You will help optimize our digital workplace through intelligent automation while contributing to a mission-critical Strategic AI Project: leveraging data to identify patients for life-changing therapies. This work is a key step toward making our predictive models more transparent, trusted, and actionable for commercial decision-making. Key Responsibilities Modern Workplace & Collaboration M365 Support: Assist in the configuration, customization, and support of Microsoft 365 applications, including SharePoint, Teams, and OneDrive. Digital Workspace: Support the development and maintenance of SharePoint sites, lists, and permissions to improve cross-functional collaboration. Workflow Optimization: Partner with IT and business teams to identify and document opportunities for efficiency improvements using modern workplace tools. Intelligent Automation & Scripting Low-Code Solutions: Build and enhance automated workflows using Power Automate to streamline data movement and business processes. Technical Scripting: Develop and maintain basic Python scripts and SQL queries for data processing, system integration, and automation tasks. AI Enablement: Explore and apply Generative AI use cases (e.g., ChatGPT) to increase team productivity and technical documentation efficiency. Data Insights & AI Transparency (Strategic Project) AI-Driven Analysis: Utilize Databricks and Databricks Genie to perform exploratory data analysis (EDA) on healthcare datasets to uncover patient trends and patterns. Visualization: Translate complex predictive model outputs into actionable business stories by building Power BI dashboards and reports. Model Trust: Assist in visualizing and documenting model drivers (such as SHAP values) to help business partners understand and trust AI-driven predictions. Required Skills & Qualifications Education: Currently pursuing or recently completed a degree in Information Technology, Computer Science, Data Analytics, or a related technical field. Core Tooling: Basic understanding of Microsoft 365 and a strong interest in learning the Power Platform (Power Automate, Power BI). Technical Literacy: Introductory experience with Python or SQL (ability to read, write, or edit basic scripts and queries). Analytical Mindset: Strong problem-solving skills and a curiosity for how AI and Data Science solve real-world healthcare challenges. Communication: Good documentation skills and the ability to explain technical concepts to non-technical business partners. Preferred / Nice-to-Have Skills Experience with Databricks or other cloud-based data platforms. Exposure to SharePoint site design or governance. Prior experience building low-code flows or personal technical/coding projects. What You’ll Gain Dual Mentorship: Direct guidance from technology enablement professionals with project-based exposure to the Data Science and Analytics team. Front-Row Seat to Biotech: Exposure to how data science fuels strategic decision-making in a commercial biotech environment. Modern Tech Stack: Hands-on experience with an enterprise stack including Databricks, SQL, Python, and Microsoft 365. Real-World Impact: See how your technical work directly contributes to identifying patients who need transformative medicines. Program Highlights: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Requirements: MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be able and willing to commit to a minimum 40-hour work week. Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Neuroscientist (Toxicology Research Group) Summary: The Toxicology Research Group is currently looking for a 2026 summer intern to work on a project investigating small interfering RNA (siRNA) associated neurotoxicity in the CNS. This internship is a great opportunity for a student to gain experience in multiple areas including mouse ICV (Intracerebroventricular) surgery, rodent handling and observation, tissue collection, and RNA extraction for qPCR and DGE (Differential Gene Expression). The student will learn how to design an experiment, interpret results and present their findings. This project will give them hands on experience in a working biotech lab and strengthen their research skills. Program Highlights: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Requirements: MUST have a High School Diploma or GED MUST be currently enrolled in a U.S. Undergraduate Degree Program and not graduating prior to the completion of the Ionis internship MUST be able to begin internship between 6/8/26 and no later than 6/14/26 MUST be able and willing to commit to a minimum 40-hour work week MUST be able and willing to remain in program through at least 8/14/26 Housing/Travel assistance available for eligible, out-of-area interns Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Evaluation of CNS cell-specific efficacy of oligonucleotides by systemic delivery Summary: We are actively working on targeting CNS after systemic delivery with oligonucleotides. Targeting the relevant cell types in the CNS is crucial to the treatment of neurological diseases. Therefore, the proposed project will focus on evaluating the level of target engagement in specific cell types in the CNS after the systemic delivery of oligonucleotides using single cell sequencing in vivo. The intern involved in this project will learn: RNA technologies and fundamental neuroscience Anatomical localization and dissection of distinct CNS regions in vivo RNA extraction and quantitative PCR Single cell RNA sequencing (scRNA-seq) Skills and Requirements: Interest and basic understanding of neuroscience Experience in general lab techniques Understanding the basics of RNA extraction and RT-PCR Experience handling mouse Program Highlights: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Requirements: MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be able and willing to commit to a minimum 40-hour work week. Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Business Development Summary: Across the biopharma industry, business development (BD) teams serve as a unique, cross-functional window into the external landscape. Companies like Ionis leverage external partnerships to bring more drugs to patients than they otherwise might be able to on their own. The Ionis Business Development team has always looked for ways to leverage external partnerships to complement Ionis’ portfolio. The Business Development Intern will support the Ionis Business Development team through two areas of focus. The first area of focus for this internship will be to generate BD ideas for Ionis by (1) mapping current and future core capabilities across our portfolio; (2) identifying potential disease areas and end markets that we could enter or better serve; and (3) providing recommendations to develop internal assets/technologies or acquire rights to external assets/technologies. A secondary area of focus for the internship will be to improve the transaction process by (1) reviewing the current market for key transaction terms and (2) designing systems to better organize the transaction process The intern will have multiple opportunities to meet leaders across the organization, attend BD meetings, and present their work to the BD and alliance management (AM) leadership. Projects the intern will work on will have direct impact on business development strategy and inform ongoing negotiations Responsibilities: Conduct market research across a range of topics, which may include the current standard of care for diseases, identification of potential therapeutic ideas for diseases enabled by emerging platform technologies, clinical-stage asset landscapes, or analyses of public contracts Design systems to improve the BD/AM transaction processes, which may include knowledge repositories, reference documents, executive presentation templates, transaction post-mortems, or workflow tools Monitor market and industry trends Review prior deals, transaction terms, and contracts to identify patterns, benchmarks, and potential best practices that can inform BD negotiations Synthesize findings into summaries, presentations, or frameworks Expectations: The Business Development Intern is expected to bring strong analytical skills, intellectual curiosity, and a foundation in scientific training. The intern should be comfortable working with complex and sometimes ambiguous information, across a variety of disciplines, and be able to structure research findings into logical outputs. Experience in corporate/business development, investment banking, hedge funds, or the biopharma industry is welcome but not required. This role is designed for candidates who are eager to learn how scientific insight is translated into business decision-making in a biopharma context. The intern is expected to demonstrate: Coachability, intellectual flexibility, and resourcefulness Ability to thrive in a fast-paced environment Logical and quantitative thinking, with the ability to quickly learn new subject matter Clear written and verbal communication skills Program Highlights: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Requirements: MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be able and willing to commit to a minimum 40-hour work week. Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Formulation & Delivery Sciences Summary: Lipid nanoparticles (LNPs) are advantageous delivery vehicles because they can be engineered to encapsulate therapeutic nucleic acid cargoes and have been used extensively in the clinic for several applications including the Pfizer/BioNTech and Moderna COVID-19 vaccines. While LNPs are successfully delivered to the liver after intravenous administration, access to non-liver (extrahepatic) tissues is difficult. To address this issue, LNPs can engineered to target extrahepatic tissues. This summer internship project will involve the design and formulation of LNPs for extrahepatic delivery, then assessing LNP activity in vitro and tissue tropism in vivo. The intern will be a member of a dynamic team and gain valuable biotechnology skills including lipid nanoparticle formulation and characterization, cell culture, fluorescence microscopy, and data analysis. Responsibilities: •Contribute to the design, production, characterization, and testing of LNPs •Assess LNP binding to cells in vitro, and assist with maintenance of cell lines •Assist with in vivo work as needed •Thoroughly document results in electronic lab notebooks and present findings •Analyze experimental data and present scientific results Expectations: •A team player who can work with a cross-functional teams in a fast-paced, entrepreneurial environment •Excellent organizational and written/verbal communication skills •Experience formulating and characterizing lipid nanoparticles and/or experience with cell culture and in vivo work is a plus Program Highlights: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments Requirements: MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be able and willing to commit to a minimum 40-hour work week. Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! Patient Marketing SUMMARY: This summer internship offers a hands-on opportunity to support patient marketing and digital engagement efforts for donidalorsen, a recently launched therapy and cornerstone asset in the Ionis portfolio. As Ionis continues to evolve as a fully integrated biotech company, this role will contribute to strengthening patient-centric communication channels and enhancing the overall patient experience in a rare disease setting. Reporting to the Patient Marketing Lead, the Summer Intern, Patient Marketing will support ongoing post-launch initiatives with a focus on social media channel optimization, content strategy, moderation, and customer experience platform refinement ABOUT THE DISEASE & THERAPY: Hereditary angioedema (HAE) is a rare genetic disease characterized by unpredictable and potentially life-threatening swelling of the arms, legs, face, gastrointestinal tract, and throat. donidalorsen, a plasma kallikrein (PKK) inhibitor, was developed to help prevent HAE attacks by targeting a key driver of inflammation. Following its launch, Ionis remains focused on ensuring patients receive clear, meaningful, and supportive communications throughout their treatment journey. KEY RESPONSIBILITIES The intern will support the patient marketing team across several post-launch priorities, including: Social Media Channel Management & Optimization Support ongoing management and optimization of patient-facing social media channels Assist with content scheduling, performance tracking, and insights reporting Help monitor and moderate comments and messages in accordance with compliance and safety guidelines Support social listening efforts to identify trends and patient needs Moderation & Community Engagement Assist with daily moderation workflows and documentation Help identify opportunities to improve patient engagement and responsiveness Customer Experience Platform Support Assist in fine-tuning patient communication streams across customer experience platforms Support optimization of patient journeys, messaging cadence, and channel performance Help test and document enhancements to digital communication workflows Cross-Functional Collaboration Partner with marketing, digital, medical, legal, and agency teams to support post-launch initiatives Contribute to ad hoc projects focused on patient engagement and experience optimization QUALIFICATIONS: Currently pursuing a bachelor’s or master’s degree in marketing, communications, life sciences, public health, or a related field Strong interest in patient-centric marketing the pharmaceutical/biotech industry, digital engagement, and healthcare innovation Familiarity with social media platforms and digital communication tools Strong organizational skills and attention to detail Ability to work collaboratively in a fast-paced, cross-functional environment Curiosity, initiative, and a desire to learn within a biotech/pharma setting PROGRAM HIGHLIGHTS: The program is designed to complement a student’s undergraduate and/or graduate studies with relevant, hands-on industry experience Ionis offers paid positions Weekly stipend (for onsite interns only) Professional Networking End-of-program project presentations Housing/Travel assistance available for eligible, out-of-area interns Networking and bonding social events Interaction with diverse and motivated teams/departments REQUIREMENTS: MUST be currently enrolled in a U.S. Undergraduate and/or Graduate Degree Program and not graduating prior to the completion of the Ionis internship. MUST be able to begin internship between 6/8 and 8/14/2026. MUST be able and willing to remain in program through at least 8/14/2026. MUST be able and willing to commit to a minimum 40-hour work week. Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position The pay scale for this position is $18 to $23 per hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. APPLICATION DEADLINE IS April 30, 2026. PLEASE INCLUDE A COVER LETTER RELEVANT TO THE POSITION APPLYING FOR. THE EVALUATION PROCESS MAY COMMENCE PRIOR TO THIS DEADLINE. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.